Description
Complement factor H (CFH, H factor 1) is a 1213-residue plasma glycoprotein that regulates the function of the alternative complement pathway. The CFH gene encodes a 155-kDa protein containing 20 tandem complement control protein (CCP) modules, also known as short consensus repeats (about 60 amino acids each), and an alternative spliced 45-kDa protein. It binds to C3b to accelerate the decay of the C3 convertase C3bBb and also acts as a cofactor for complement factor I-mediated C3b cleavage. Human CFH is particularly important for selectively protecting self-surfaces by binding to glycosaminoglycans on host cells